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Menopace ISO

Menopace ISO 30 Tablets Monthly Pack

619
List price: 693
Short description:
Menopace ISO is a safe alternative to HRT and world’s first ever non hormonal scientifically formulated nutrient therapy for the treatment of menopausal symptoms. Menopace ISO is an accurately balanced combination of Isoflavones, specific micronutrients and select antioxidants which...
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Menopace ISO is a safe alternative to HRT and world’s first ever non hormonal scientifically formulated nutrient therapy for the treatment of menopausal symptoms.

Menopace ISO is an accurately balanced combination of Isoflavones, specific micronutrients and select antioxidants which play a major role in supporting the woman’s body in its own natural processes during and after menopause.

Composition: Each film coated tablet contains
Soy isoflavones – 100 mg Biotin – 30 mcg
Vitamin A – 2500 IU P.A.B.A – 25 mg
Vitamin C – 75 mg Cal pantothenate – 20 mg
Vitamin D3 – 600 IU Iron – 12 mg
Vitamin E – 20 mg Boron – 2 mg
Vitamin B12 – 9 mcg Zinc – 15 mg
Folic acid – 500 mcg Magnesium – 100 mg
Nicotinamide – 20 mg Mangnese – 0.5 mg
Vitamin B1 – 15 mg Iodine – 225 mcg
Riboflavin(B2) – 3 mg Chromium – 80 mcg
Pyridoxin(B6) – 20 mg Selenium – 100 mcg

Brand positioning: In peri and post Menopausal Women

Punch line: Combats menopausal symptoms effectively.

USP’S of Menopace ISO
• Offers Right strength of isoflavones 100 mg
• Provides essential micronutrients and free radical fighters.
• Relieves perimenopausal symptoms and reduces post menopausal risk.
• Offers patients compliances with OD dosage.
• Synergistic combination well documented & endorsed for management of menopausal symptoms by all Gynecologists & Physicians

Indications:
- Perimenopause
- Postmenopause
- Surgical Menopause
- Switch over from HRT

Dosage : One Tablet once daily

Menopause

menopace-womanMenopause is defined as permanent end of menstruation and fertility, which occurs between the ages of 45-55. (Ovaries stop producing estrogen).

Most women reach menopause between the ages of 45 and 55, but menopause may occur as earlier as the 30s or 40s or may not occur until a woman reaches her 60s.
As a rough “rule of thumb,” women tend to undergo menopause at an age similar to that of their mothers.

Perimenopause
Perimenopause is the phase before menopause, when ovarian hormone production is declining and fluctuating, causing host of symptoms.

The hormonal changes associated with menopause actually begin prior to the last menstrual period, during a three to five year period called the perimenopause.

Around the time of menopause, women often lose bone density and their blood cholesterol levels may worsen, increasing their risk of heart disease.
Perimenopause is different for each woman.

Surgical Menopause
Surgical menopause is when the ovaries are removed prior to natural menopause. This causes a sudden and permanent drop of the ovarian hormones. In surgical menopause the symptoms may commence very quickly and often the symptoms are intense

Perimenopausal & Menopausal Symptoms

It is important to remember that each woman’s experience is highly individual. Some women may experience few or no symptoms of menopause, while others experience multiple physical and psychological symptoms. The extent and severity of symptoms varies significantly among women.

Benefits of Isoflavones in Menopause

Isoflavones give many health benefits to menopausal woman like
• Isoflavones relieves menopause symptoms
• Improves bone health
• Lowers cholesterol
• Lower cancer risk

Right strength of Isoflavones
100 is a clinically proven conclusion and the right strength of isoflavones

Clinical Evidence

“100mg Isoflavones is safe and effective alternative therapy for menopausal symptoms”
Obstet Gynecol.2002:99(3):389-94

“Isoflavones supplementation substantially reduces the frequency of hot flushes”
Obstet Gynecol.2001:Oct:98(4):702

“Isoflavone supplementation, 100 mg/day could not only prevent menopausal bone resorption but also increase BMD & decrease body fat”.
Clin Exp Pharmacol Phvsiol 2004:31 Suppl 2:S39-S41

“Isoflavones significantly reduced serum total cholesterol, LDL cholesterol, and triglycerides”
Am J Clin Nutr. 2005 Feb;81(2):397-408

“100 mg Isoflavones increase BMD and decrease body fat concomitantly with BMI reduction and prevent osteoporosis in menopausal women”
Nutrition Journal 2005,1186/1475-2891-4-30

“100 mg Isoflavones prevent menopausal bone resorption, increase BMD and decrease body mass index”
Clinical and Experimental Pharmacology and Physiology 2004; 31(2): S39

“100 mg Isoflavones offer benefits to the Cardiovascular system by reducing Cholesterol and LDL significantly”
Obstet Gynecol. 2002; 99(3):389-94

“Isoflavones significantly reduces total cholestrol, LDL, triglycerides and significantly increases HDL
Am J Cardiol, 2006 sep 1:98(5):633-40

“Isoflavones appear to have coronary benefits independent of cholesterol reduction”.
Eur J Clin Nutr 57: 940, 2003: Nutr 19:280,2003:

“Daily Supplementation of Soy isoflavones reduces Menopausal symptoms”.
Menopause 2012 Jul;19(7):791-8

Role of Micronutrients
Specific micronutrients reduce the body’s sensitivity to decreasing estrogen levels and thus reduces intensity and frequency of perimenopausal symptoms.

Clinical Evidence :

“Recent clinical evidence suggests that many of the menopausal problems can be considerably reduced and often resolved by optimizing the intake of specific nutrients”
“Value of micronutrient supplements in the prevention or correction of disorders
accompanying the menopause” Rev Fr Gynecol.Obstect 85(12): 702:1990”

The Internet Journal of Gynecology and Obstetrics ISSN:1528-8439
Dr Suchitra Pandit Professor, Dept og Gyn&Obs,LTM Medical College Mumbai
Evaluation of the efficacy and tolerability of Micronutrient supplementation in treatment of Post Menopausal Symptoms.
Conclusion: Findings suggest that the multiple micronutrient supplements are effective in improving postmenopausal symptoms of hot flushes, night sweats, insomnia, depression, tiredness and for improving feeling of well-being,

“Vitamin E improves heat regulation capacity of the body and hence relieve the hot flushes”

“Vitamin E, A, C & Zinc maintains integrity and secretions of vaginal membrane”.

“Vitamin B6, Folic acid, Niacin & Magnesium reduces the anxiety and depression by controlling serotonin levels”

“Chromium, Magnesium, Zinc, Vitamin C, B6, & Vitamin B1 help control glucose balance’

“Low intake of folic acid, vitamin B6 & B12 have been demonstrated to be associated with Hyperhomocysteinemia (high levels of homocysteine), a potent and independent risk factor for CHD’

‘Magnesium, Copper, manganese, Zinc and other trace elements are essential for optimal bone matrix development and bone density sustenance in post menopausal woman.
J Am Coll Nutr, 1993. Aug:12(4): 384-9

Free radical fighters – Selenium, Vitamin E, C and A
• Reduces oxidative stress, so common with ageing and in menopausal women.
• Antioxidants help to prevent atherosclerosis.

Treatment option for Menopause

treatment-optionHormone replacement therapy for Menopause
In HRT synthetic estrogen, progesterone is given to boost hormone levels.
There are a number of risks and side effects associated with HRT
Side effects include poor compliance and need for very long term treatment.
WHI trial involving 16000 healthy women on HRT aged 50 was stopped due to increased risk of:
• Breast cancer – 26%
• CHD – 29%
• Stroke – 41%

(July 17,2002-Vol 288:Pg.321-333 JAMA.)

Phytoestrogen (Isoflavone)
Isoflavones are polyphenolic compounds that are capable of exerting estrogen like effects. For this reason, they are classified as phytoestrogens
Isoflavones are structurally similar to the mammalian estrogen, estradiol.
Because of this similarity in structure, they mimic the action of estrogen and provide estrogenic benefits.

Estrogen Receptors
There are alpha and beta receptors for estrogen. Estrogens like all hormones act by binding to receptors located on the cell, which provokes reactions.

The alpha-receptors are linked with a risk of estrogen related cancers. On the other hand, the beta-receptors initiate only favorable effects. The repartation of these 2 types of receptors in the cells and organs is different. Different tissues appear to have different ratios of each receptor type.
Isoflavones appear to bind better to estrogen receptor-beta than to estrogen receptor-alpha.

Post menopausal Risk

Osteopenia
Osteopenia refers to bone mineral density (BMD) that is lower than normal peak BMD but not low enough to be classified as Osteoporosis.

Osteoporosis
The word osteoporosis literally means “porous bones.” It occurs when bones lose an excessive amount of their protein and mineral content, particularly calcium. Over time, bone mass, and therefore bone strength, is decreased. As a result, bones become fragile and break easily.

PMO(post-menopausal osteoporosis) occurs in women after menopause.
Decline in estrogen level, accelerates bone loss rapidly. Bone remodeling activity gets disturbed leading to increase in activity of osteoclasts and decrease in activity of osteoblasts. Continuous resorption of bone calcium, results into bones becoming porous, brittle and prone to fractures.

Coronary Heart Disease
Estrogen deficiency leads to increase in LDL and triglycerides and fat deposition in arteries leading to vulnerability for atherosclerosis

coronary-heart-disease
Need of the hour is:

To relieve Perimenopausal symptoms
To minimize the Post menopausal risks

35 Symptoms of Perimenopause & Menopause

01. Hot flashes, night sweats and or cold flashes, clammy feeling
02. Irregular heart beat
03. Tingling in the extremities
04. Irritability
05. Mood swings, sudden tears
06. Trouble sleeping through the night (with or without night sweats)
07. Irregular periods: shorter, lighter, heavier, flooding, phantom periods; shorter cycles;
longer cycles
08. Dry vagina
09. Osteoporosis (after several years)
10. Crashing fatigue
11. Anxiety, feeling ill at ease
12. Feelings of dread, apprehension, doom
13. Difficulty concentrating, disorientation, mental confusion
14. Disturbing memory lapses
15. Incontinence, especially upon sneezing, laughing; urge incontinence
16. Itchy, crawly skin
17. Changes in fingernails: softer, crack or break easier
18. Aching, sore joints, muscles and tendons
19. Increased tension in muscles
20. Breast tenderness
21. Tinnitus: ringing in ears, bells, etc
22. Headache change: increase or decrease
23. Gastrointestinal distress, indigestion, flatulence, gas pain, nausea
24. Sudden bouts of bloat
25. Depression
26. Loss of libido
27. Exacerbation of existing conditions
28. Increase in allergies
29. Weight gain
30. Thinning or loss of hair of head, pubic, or whole body;increase in facial hair
31. Dizziness, light-headedness, episodes of loss of balance
32. Changes in body odor
33. Electric shock sensation under the skin and in the head
34. Gum problems, increased bleeding
35. Burning tongue, burning roof of mouth, bad taste in mouth, change in breath odor.